Semaglutide vs Liraglutide
A side-by-side comparison of Semaglutide and Liraglutide, including efficacy data, side effects, dosing, and cost.
Feature
Semaglutide
Liraglutide
Drug Class
GLP-1 receptor agonist
GLP-1 receptor agonist
Brand Names
Ozempic, Wegovy, Rybelsus
Saxenda, Victoza
Form
Once-weekly injection (Ozempic, Wegovy) or daily tablet (Rybelsus)
Daily injection
Dosing
0.25 mg → 0.5 mg → 1 mg → 2 mg (weekly injection); 3 mg → 7 mg → 14 mg (daily tablet)
0.6 mg → 1.2 mg → 1.8 mg → 2.4 mg → 3.0 mg (daily)
FDA Approval
Type 2 diabetes (Ozempic, Rybelsus); Chronic weight management (Wegovy)
Type 2 diabetes (Victoza); Chronic weight management (Saxenda)
Efficacy
Average 15-17% body weight loss over 68 weeks (STEP trials)
Average 5-8% body weight loss over 56 weeks (SCALE trials)
Cost
$900-$1,400/month without insurance
$1,200-$1,600/month without insurance
Semaglutide Side Effects
- •Nausea
- •Vomiting
- •Diarrhea
- •Constipation
- •Abdominal pain
- •Headache
Liraglutide Side Effects
- •Nausea
- •Diarrhea
- •Constipation
- •Vomiting
- •Headache
- •Decreased appetite
Which one should you choose?
The best medication depends on your health goals, insurance coverage, and how your body responds.
Always consult your healthcare provider before starting or switching medications.