Zepbound and Saxenda are both FDA-approved for weight loss. They use different drugs and very different dosing schedules.
Quick Comparison
| Zepbound | Saxenda | |
|---|---|---|
| Active drug | Tirzepatide | Liraglutide |
| Drug class | Dual GIP/GLP-1 agonist | GLP-1 agonist |
| FDA approval | Weight management | Weight management |
| Injection frequency | Once weekly | Once daily |
| Dose range | 2.5 mg – 15 mg | 0.6 mg – 3 mg |
| Maker | Eli Lilly | Novo Nordisk |
How They Work
Zepbound mimics two hormones (GLP-1 and GIP) that signal fullness and slow digestion.
Saxenda mimics one hormone (GLP-1) that does the same thing.
Weight Loss Results
- Zepbound: ~21% body weight loss on average at max dose
- Saxenda: ~5-8% body weight loss on average at max dose
Zepbound produces significantly more weight loss. The dual-hormone approach makes a big difference.
Side Effects
Both cause similar GLP-1 side effects:
- Nausea (most common)
- Diarrhea or constipation
- Decreased appetite
- Stomach pain
- Fatigue
- Headache
Side effects are worst when you start and after dose increases. Most people adjust within a few weeks.
Convenience
- Zepbound: One injection per week
- Saxenda: One injection per day
Weekly is much more convenient for most people.
Cost
Zepbound: ~$1,060/month Saxenda: ~$1,300-1,400/month
Zepbound is cheaper at list price and produces more weight loss. But your insurance will decide which you can actually get.
Who Should Choose Zepbound?
- You want the strongest weight loss results
- You want weekly injections
- Your insurance covers it
- You're starting fresh
Who Should Choose Saxenda?
- Your insurance covers it and not Zepbound
- You've used it before and it works
- You prefer daily dosing
- You can't tolerate tirzepatide
Bottom Line
Zepbound is newer, weekly, cheaper, and produces much more weight loss. Saxenda is older, daily, and still works for many people.
Talk to your doctor about which makes sense for your situation.
Work with your healthcare provider to determine which medication is right for you. Individual results and experiences vary.